The relationship between bronchoalveolar lavage fluid cytology and airway hyper‐reactivity in a population of Australian horses presented for poor performance
| Autor: | C.J. Secombe, Mieghan Bruce, Guy D. Lester, A. W. van Eps |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Population Athletic Performance Bronchoalveolar Lavage Gastroenterology Pulmonary function testing 0403 veterinary science chemistry.chemical_compound Internal medicine Respiratory Hypersensitivity medicine Animals Plethysmograph Horses education education.field_of_study General Veterinary medicine.diagnostic_test business.industry Australia 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine respiratory system Eosinophil Mast cell 040201 dairy & animal science Asthma Respiratory Function Tests respiratory tract diseases Cross-Sectional Studies medicine.anatomical_structure Bronchoalveolar lavage chemistry Horse Diseases Airway business Bronchoalveolar Lavage Fluid Histamine |
| Zdroj: | Australian Veterinary Journal. 97:343-350 |
| ISSN: | 1751-0813 0005-0423 |
| DOI: | 10.1111/avj.12861 |
| Popis: | Objective: To investigate the relationship between bronchoalveolar lavage fluid cytology, particularly mast cells, and airway hyper-reactivity in athletic horses presented for poor performance that included a respiratory tract evaluation in two disparate locations in Australia. Design: Multi-centre, retrospective and prospective cross-sectional study. Methods: Eighty four adult horses underwent both pulmonary function testing and histamine bronchoprovocation with a commercial flowmetric plethysmography system. A bronchoalveolar lavage was performed four to twelve hours later. Bronchoalveolar lavage fluid cytology was categorised using two differing classification systems to define mild equine asthma. Statistical analysis was used to assess associations between bronchoalveolar lavage fluid relative inflammatory cell percentages, and airway hyper-reactivity and their associated categorisations. Results: Sixty four percent (54/84) of horses displayed airway hyper-reactivity, as defined by PC 2% and/or relative neutrophil percentage > 5% and/or eosinophil relative cell percentage ≥ 1%) displayed airway hyper-reactivity at a lower dose of nebulized histamine than horses with normal bronchoalveolar lavage fluid cytology. Conclusion: In the Australian context, recently revised increased bronchoalveolar lavage fluid cytology relative cell percentage cut offs appear appropriate for sole mast cell responses. The historical lower cut offs appear to be appropriate for mixed inflammatory cell responses. |
| Databáze: | OpenAIRE |
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