Actionable gene alterations in an Asian population with triple-negative breast cancer
| Autor: | Seigo Nakamura, Shujiro Okuda, Hideko Yamauchi, Stephen Lyle, Kazuhiro Yoshida, Toshifumi Wakai, Manabu Futamura, Yoshifumi Shimada, Yuko Kitagawa, Kazuaki Takabe, Tetsu Hayashida, Chie Toshikawa, Hiroshi Ichikawa, Masato Nakajima, Junko Tsuchida, Nobuaki Sato, Takashi Kuwayama, Yi Wei Ling, Chizuko Kanbayashi, Koji Kaneko, Yasuo Miyoshi, Masayuki Nagahashi, Teruo Yamauchi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Ethnic populations Biology medicine.disease Article 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine Cancer genome medicine Asian population Cancer gene Independent data Gene Triple-negative breast cancer |
| Zdroj: | JCO Precis Oncol |
| ISSN: | 2473-4284 |
| Popis: | Purpose It has been suggested that the biologic characteristics of breast cancer may differ among different geographic or ethnic populations. Indeed, triple-negative breast cancer (TNBC), the most lethal breast cancer subgroup, has been reported to occur at a higher incidence in Japan than in the United States. However, most genomic studies of these tumors are from Western countries, and the genomic landscape of TNBC in an Asian population has not been thoroughly investigated. Here, we sought to elucidate the geographic and ethnic diversity of breast cancer by examining actionable driver alterations in TNBC tumors from Japanese patients and comparing them with The Cancer Genome Atlas (TCGA) database, which gathers data primarily from non-Asian patients. Materials and Methods We performed comprehensive genomic profiling, including an analysis of 435 known cancer genes, among Japanese patients with TNBC (n = 53) and compared the results with independent data obtained from TCGA (n = 123). Results Driver alterations were identified in 51 (96%) of 53 Japanese patients. Although the overall alteration spectrum among Japanese patients was similar to that of TCGA, we found significant differences in the frequencies of alterations in MYC and PTK2. We identified three patients (5.7%) with a high tumor mutational burden, although no microsatellite instability was observed in any of the Japanese patients. Importantly, pathway analysis revealed that 66.0% (35 of 53) of Japanese patients, as well as 66.7% (82 of 123) of TCGA cohort, had alterations in at least one actionable gene targetable by US Food and Drug Administration–approved drug. Conclusion Our study identified actionable driver alterations in Japanese patients with TNBC, revealing new opportunities for targeted therapies in Asian patients. |
| Databáze: | OpenAIRE |
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