Hepatic structure and function after modified jejunoileal bypass surgery for obesity
| Autor: | W H Butler, T R Pilkington, J C Gazet, I Sanderson, J D Maxwell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1977 |
| Předmět: |
Adult
Male medicine.medical_specialty Bilirubin medicine.medical_treatment Jejunoileal bypass Ileum Jejunum chemistry.chemical_compound Postoperative Complications Weight loss Intestine Small medicine Humans Obesity Adverse effect General Environmental Science business.industry General Engineering General Medicine Middle Aged medicine.disease Surgery medicine.anatomical_structure chemistry Liver General Earth and Planetary Sciences Female Liver function Steatosis medicine.symptom business Research Article |
| Popis: | The most serious adverse effect of standard intestinal bypass for obesity is the high incidence of hepatic dysfunction and death from hepatic failure. We therefore examined the long-term effects of a modified form of jejunoileal bypass (in which a greater continuous length of ileum is retained), on liver function in 120 patients. Substantial weight loss (119-0+/-SD 23-3 kg to 82-3+/-18-8 kg) occurred during the first nine months after surgery, accompanied by a significant rise in serum concentrations of bilirubin, alanine transferase, and alkaline phosphatase, and a significant reduction in albumin concentrations. Biochemical changes were unrelated to weight loss or halothane anaesthesia. After weight stabilisation liver function reverted to normal, and four years after bypass sulphobromophthalein retention and hepatic histology did not differ from those in obese controls. There were two postoperative deaths. Three other patients died during the period of rapid weight loss with severe hepatic steatosis. While transient mild impairment of liver function is common after modified jejunoileal bypass, clinically significant hepatic dysfunction is a rare and unexplained early complication. |
| Databáze: | OpenAIRE |
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