The MicroRNA‐326: Autoimmune diseases, diagnostic biomarker, and therapeutic target
| Autor: | Khalil Ansarin, Shahriar Alipour, Ebrahim Sakhinia, Golamreza Jadideslam, Farhad Pouremamali, Alireza Khabbazi |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Physiology Clinical Biochemistry Inflammation Adaptive Immunity medicine.disease_cause Autoimmune Diseases Epigenesis Genetic Autoimmunity 03 medical and health sciences microRNA Humans Medicine Diagnostic biomarker Molecular Targeted Therapy Epigenetics Pathological business.industry Cell Biology Immune dysregulation Acquired immune system MicroRNAs 030104 developmental biology Gene Expression Regulation Immunology medicine.symptom business |
| Zdroj: | Journal of Cellular Physiology. 233:9209-9222 |
| ISSN: | 1097-4652 0021-9541 |
| Popis: | MicroRNAs (miRNAs) are uniquely regulated in healthy, inflamed, activated, cancerous, or other cells and tissues of a pathological state. Many studies confirm that immune dysregulation and autoimmune diseases with inflammation are correlated with various miRNA expression changes in targeted tissues and cells in innate or adaptive immunity. In this review, we will explain the history and classification of epigenetic changes. Next, we will describe the role of miRNAs changes, especially mir-326 in autoimmunity, autoinflammatory, and other pathological conditions. A systematic search of MEDLINE, Embase, and Cochrane Library was presented for all related studies from 1899 to 2017 with restrictions in the English language. In recent years, researchers have concentrated on mostly those roles of miRNA that are correlated with the inflammatory and anti-inflammatory process. Latest studies have proposed a fundamental pathogenic role in cancers and autoinflammatory diseases. Studies have described the role of microRNAs in autoimmunity and autoinflammatory diseases, cancers, and so on. The miRNA-326 expression plays a significant role in autoimmune and other types of diseases. |
| Databáze: | OpenAIRE |
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