Early prediction of chronic oxygen dependency by lung function test results
| Autor: | Gabriel Dimitriou, Anne Greenough, V Kavvadia |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Gestational Age Pulmonary function testing Positive-Pressure Respiration Functional residual capacity Predictive Value of Tests Oxygen therapy medicine Humans Infant Very Low Birth Weight Lung volumes Hypoxia Respiratory Distress Syndrome Newborn Respiratory Care Units business.industry Infant Newborn Oxygen Inhalation Therapy Gestational age Sequela medicine.disease Respiratory Function Tests Surgery Oxygen Breath Tests Premature birth Anesthesia Chronic Disease Pediatrics Perinatology and Child Health Gestation business |
| Zdroj: | Pediatric Pulmonology. 29:19-26 |
| ISSN: | 1099-0496 8755-6863 |
| Popis: | Chronic oxygen dependency (COD) is a common sequela to very premature birth. Steroid therapy may reduce COD if given within the first 2 weeks, but has important side effects. It is, therefore, crucial to identify an accurate predictor of COD and hence only expose high-risk infants to intervention therapy. The aim of this study was to determine if, within 48 hr of birth, abnormal lung function predicted COD and whether such results performed better than readily available clinical data. Results from 100 consecutive, very low birth-weight infants, median gestation age 28 weeks (range, 24–33), who were ventilated within 6 hr of birth and survived beyond 36 weeks postconceptional age (PCA), were analyzed. Lung volume was assessed by measurement of functional residual capacity (FRC) using a helium gas dilution technique, and compliance was measured using either a passive inflation or an occlusion technique. The maximum peak inflating pressure and inspired oxygen concentration within the first 48 hr were recorded. The infants who remained oxygen-dependent beyond 28 days (n = 58) and 36 weeks PCA (n = 24) differed from the rest in being more immature (P < 0.001), more had a patent ductus arteriosus, and they had both a lower median lung volume (P < 0.001) and lower compliance (P < 0.01) on day 2. An FRC |
| Databáze: | OpenAIRE |
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