Effect of a novel anti-rheumatic drug, TA-383, on type II collagen-induced arthritis
| Autor: | Masakazu Takeshita, Isao Takata, Makoto Ueno, Kazunori Imaizumi, Takahisa Sugita |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Immunology Type II collagen Anti-Inflammatory Agents Arthritis Pharmacology Lobenzarit Dexamethasone Mice Arthropathy medicine Animals Humans ortho-Aminobenzoates Chemotherapy business.industry Anti-Inflammatory Agents Non-Steroidal Imidazoles medicine.disease Arthritis Experimental Mice Inbred DBA Rheumatoid arthritis Immunoglobulin G Histopathology Collagen business medicine.drug |
| Zdroj: | International journal of immunopharmacology. 17(7) |
| ISSN: | 0192-0561 |
| Popis: | The effects of TA-383 (0.016, 0.08, 0.4, 2 and 10 mg/kg) and anti-rheumatic drugs (lobenzarit 10 and 50 mg/kg, dexamethasone 0.25 mg/kg) were evaluated on type II collagen-induced arthritis in DBA/1J mice. The arthritis score was markedly suppressed in the groups treated with dexamethasone and TA-383. Serum anti-type II collagen IgG was significantly suppressed in the groups treated with dexamethasone and 0.4 mg/kg TA-383. Histopathological evaluation of the knee joints revealed suppression of the inflammatory changes in the groups treated with dexamethasone and TA-383. These findings suggest that the histopathological examination of the joints of the animal model is useful for the evaluation of anti-rheumatic drugs, and that TA-383 has suppressive effects on type II collagen-induced arthritis, an animal model for human rheumatoid arthritis. |
| Databáze: | OpenAIRE |
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