The distribution of HLA haplotypes in the ethnic groups that make up the Brazilian Bone Marrow Volunteer Donor Registry (REDOME)
| Autor: | Danielli C. M. Oliveira, Noemi F. Pereira, R. A. Fabreti-Oliveira, M. E. Moraes, Matilde Romero, Michael Halagan, Jeane Eliete Laguila Visentainer, Luís Cristóvão Porto, Juliana Fernandes Cardoso, Martin Maiers |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Volunteers
0301 basic medicine Immunology Population Ethnic group Human leukocyte antigen Biology 03 medical and health sciences Race (biology) 0302 clinical medicine Gene Frequency Bone Marrow HLA Antigens Genetic variation Ethnicity Genetics Humans Registries Allele education Allele frequency Alleles education.field_of_study Histocompatibility Antigens Class I Haplotype Genetic Variation Tissue Donors 030104 developmental biology Haplotypes Brazil 030215 immunology Demography |
| Zdroj: | Immunogenetics. 70:511-522 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/s00251-018-1059-1 |
| Popis: | The Registries of Bone Marrow Donors around the world include more than 30 million volunteer donors from 57 different countries, and were responsible for over 17,000 hematopoietic stem cell transplants in 2016. The Brazilian Bone Marrow Volunteer Donor Registry (REDOME) was established in 1993 and is the third largest registry in the world with more than 4.3 million donors. We characterized HLA allele and haplotypes frequencies from REDOME comparing them with the donor self-reported race group classification. Five-locus haplotype frequencies (A~C~B~DRB1~DQB1) were estimated for each of the six race groups, resolving phase and allelic ambiguity using the expectation-maximization (EM) algorithm. The top 100 haplotypes in the race groups were separated into eight clusters of haplotypes, based on haplotype similarity, using CLUTO. We present HLA allele and haplotype frequency data from six race groups from 2,938,259 individuals from REDOME. The most frequent haplotype was the same for all groups: A*01:01g~C*07:01g~B*08:01g~DRB1*03:01g~DQB1*02:01g. Some frequent haplotypes such as A*02:01g~C*16:01g~B*44:03~DRB1*07:01g~DQB1*02:01g was not found in people with Preta (Sub-Saharan African descent). A cluster including Branca (European) and Parda or non-informed (admixed) could be distinguished from both Preta (SubSaharan) and Indígena (Amerindian) groups, and from the Amarela (Asian) ones, which clustered with their original population. These results have implications on cross-population matching and can help in donor searches and population-based recruitment strategies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink