A Nature-Inspired Metal-Organic Framework Discriminator for Differential Diagnosis of Cancer Cell Subtypes
| Autor: | Tingting Cui, Zhengwei Liu, Mengmeng Ma, Xiaogang Qu, Lu Zhang, Jinsong Ren |
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| Rok vydání: | 2021 |
| Předmět: |
Glycan
Cell Computational biology 010402 general chemistry 01 natural sciences Catalysis Diagnosis Differential Breast cancer In vivo Polysaccharides Neoplasms medicine Humans Receptor Metal-Organic Frameworks Biological Products biology 010405 organic chemistry Chemistry Imidazoles General Chemistry medicine.disease 0104 chemical sciences medicine.anatomical_structure Cancer cell biology.protein Bioorthogonal chemistry Differential diagnosis Lysosomes |
| Zdroj: | Angewandte Chemie (International ed. in English). 60(28) |
| ISSN: | 1521-3773 |
| Popis: | Metabolic glycan labeling (MGL) followed by bioorthogonal chemistry provides a powerful tool for tumor imaging and therapy. However, selectively metabolic labeling of cells or tissues of interest remains a challenge. Particularly, owing to tumor heterogeneity including tumor subtypes and interpatient heterogeneity, it is far more difficult to realize tumor-cell-selective metabolic labeling for precise diagnosis. Inspired by nature, we designed azidosugar-functionalized metal-organic frameworks camouflaged with cancer cell membranes to accomplish cancer-cell-selective MGL in vivo. With abundant receptors, this biomimetic platform not only selectively targets homotypic cells but also realizes different breast cancer subtype-selective MGL. Moreover, the endo/lysosomal-escaped ZIF-8 can make azidosugar escape from lysosomes and accelerate its metabolic incorporation. This strategy also takes advantage of cancer-tissue-derived cell membranes, which may have huge potential for personalized diagnosis and therapy. |
| Databáze: | OpenAIRE |
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