Apolipoprotein E epsilon 4 allele and nephrotic glomerular diseases in children
| Autor: | Tatiana Ciomartan, Hiroshi Hayakawa, Shuichi Tomisawa, Tadashi Asami, Makoto Uchiyama |
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| Rok vydání: | 1999 |
| Předmět: |
Apolipoprotein E
Male medicine.medical_specialty Nephrotic Syndrome Adolescent Glomerulonephritis Membranoproliferative Apolipoprotein E4 Nephropathy Focal segmental glomerulosclerosis Apolipoproteins E Glomerulonephritis Gene Frequency Internal medicine Membranoproliferative glomerulonephritis medicine Humans Child Allele frequency Alleles business.industry Glomerulosclerosis Focal Segmental Glomerulosclerosis Glomerulonephritis IGA medicine.disease Endocrinology Phenotype Nephrology Child Preschool Pediatrics Perinatology and Child Health lipids (amino acids peptides and proteins) Electrophoresis Polyacrylamide Gel Female business Nephrotic syndrome |
| Zdroj: | Pediatric nephrology (Berlin, Germany). 13(3) |
| ISSN: | 0931-041X |
| Popis: | Hyperlipidemia is a well-recognized complication of the nephrotic syndrome and is a factor contributing to the progression of the initial glomerular injury and the development of glomerulosclerosis. Apolipoprotein E (apoE) is a plasma protein and apoE epsilon 4 allele is associated with higher plasma cholesterol levels. With this in mind, we studied apoE phenotypes and alleles in children with nephrotic glomerular diseases (NGD, n=29), including idiopathic nephrotic syndrome (n=16), membranoproliferative glomerulonephritis (n=7), and focal segmental glomerulosclerosis (FSGS, n=6). Children with NGD had a higher epsilon 4 allele frequency (20.7%) than controls (10.8%), and those with FSGS had both higher apoE4/3 (66.7%) and epsilon 4 allele (33.3%) frequencies than controls (20.4% and 10.8%, respectively). In IgA nephropathy (n=30, disease controls), no significant association with specific apoE was found. Further studies are needed to clarify the significance of the observed high frequencies of apoE epsilon 4 allele in children with NGD and apoE4/3 phenotype distribution in FSGS. |
| Databáze: | OpenAIRE |
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