Perfluorocarbon-associated gas exchange improves oxygenation, lung mechanics, and survival in a model of adult respiratory distress syndrome
| Autor: | David M. Steinhorn, Beverly Kahn, Lynn J. Hernan, Pamela R. Paczan, Bradley P. Fuhrman, John E. Fisher, Corinne L. Leach, Bruce A. Holm, Michele C. Papo |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Swine
medicine.medical_treatment Positive pressure Pulmonary compliance Lung injury Critical Care and Intensive Care Medicine Positive-Pressure Respiration chemistry.chemical_compound Random Allocation medicine Animals Humans Prospective Studies Mechanical ventilation Respiratory Distress Syndrome Perflubron business.industry Pulmonary edema medicine.disease Positive pressure breathing Respiration Artificial Survival Analysis Oxygen Respiratory acidosis Disease Models Animal chemistry Anesthesia Respiratory Mechanics business |
| Zdroj: | Critical care medicine. 24(3) |
| ISSN: | 0090-3493 |
| Popis: | Objective : To compare the effectiveness of perfluorocarbon-associated gas exchange to volume controlled positive pressure breathing in supporting gas exchange, lung mechanics, and survival in an acute lung injury model. Design : A prospective, randomized study. Setting : A university medical school laboratory approved for animal research. Subjects : Neonatal piglets. Interventions : Eighteen piglets were randomized to receive perfluorocarbon-associated gas exchange with perflubron (n = 10) or volume controlled continuous positive pressure breathing (n = 8) after acute lung injury was induced by oleic acid infusion (0.15 mUkg iv). Measurements and Main Results : Arterial and venous blood gases, hemodynamics, and lung mechanics were measured every 15 mins during a 3-hr study period. All animals developed a metabolic and a respiratory acidosis during the infusion of oleic acid. Following randomization, the volume controlled positive pressure breathing group developed a profound acidosis (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|