Activity of the Hypothalamic–Pituitary–Adrenal System in Prenatally Stressed Male Rats on the Experimental Model of Post-Traumatic Stress Disorder

Autor: Svetlana Pivina, Natalia Ordyan, V. K. Akulova, V. V. Rakitskaya
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Hypothalamo-Hypophyseal System
medicine.medical_specialty
Vasopressin
Corticotropin-Releasing Hormone
Vasopressins
Pituitary-Adrenal System
General Biochemistry
Genetics and Molecular Biology
Stress Disorders
Post-Traumatic
03 medical and health sciences
chemistry.chemical_compound
Corticotropin-releasing hormone
Basal (phylogenetics)
0302 clinical medicine
Pregnancy
Corticosterone
Parvocellular cell
Internal medicine
medicine
Animals
Rats
Wistar
business.industry
General Medicine
Rats
Disease Models
Animal
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Prenatal stress
Prenatal Exposure Delayed Effects
Female
business
Nucleus
Stress
Psychological
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Paraventricular Hypothalamic Nucleus
Hormone
Zdroj: Bulletin of Experimental Biology and Medicine. 160:601-604
ISSN: 1573-8221
0007-4888
Popis: Using the experimental model of post-traumatic stress disorder (stress-restress paradigm), we studied the dynamics of activity of the hypothalamic-pituitary-adrenal system (HPAS) in adult male rats, whose mothers were daily subjected to restraint stress on days 15-19 of pregnancy. Prenatally stressed males that were subjected to combined stress and subsequent restress exhibited not only increased sensitivity of HPAS to negative feedback signals (manifested under restress conditions), but also enhanced stress system reactivity. These changes persisted to the 30th day after restress. Under basal conditions, the number of cells in the hypothalamic paraventricular nucleus of these animals expressing corticotropin-releasing hormone and vasopressin was shown to decrease progressively on days 1-30. By contrast, combined stress and restress in control animals were followed by an increase in the count of CRH-immunopositive cells in the magnocellular and parvocellular parts of the paraventricular nucleus and number of vasopressin-immunopositive cells in the magnocellular part of the nucleus (to the 10th day after restress). Our results indicate a peculiar level of functional activity of HPAS in prenatally stressed males in the stress-restress paradigm: decreased activity under basal conditions and enhanced reactivity during stress.
Databáze: OpenAIRE
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