Functional regeneration in a rat Parkinson's model after intrastriatal grafts of glial cell line-derived neurotrophic factor and transforming growth factor beta1-expressing extra-adrenal chromaffin cells of the Zuckerkandl's organ

Autor: Emilio Fernandez Espejo, Isabel Caraballo, Juan A. Flores, Fadwa El Banoua, Joao-Paulo Moraes, M. Carmen Gonzalez-Albo
Rok vydání: 2001
Předmět:
medicine.medical_specialty
Cell Transplantation
Chromaffin Cells
Dopamine
Gene Expression
Nerve Tissue Proteins
Biology
Motor Activity
Synaptic Transmission
Transforming Growth Factor beta1
Neurotrophic factors
Transforming Growth Factor beta
Internal medicine
medicine
Glial cell line-derived neurotrophic factor
Para-Aortic Bodies
Animals
Regeneration
Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factors
Parkinson Disease
Secondary
Rats
Wistar
ARTICLE
Oxidopamine
General Neuroscience
Graft Survival
Recovery of Function
Corpus Striatum
Rats
Transplantation
Substantia Nigra
Disease Models
Animal
medicine.anatomical_structure
Endocrinology
Treatment Outcome
nervous system
Adrenal Medulla
Chromaffin cell
biology.protein
GDNF family of ligands
Paraganglion
Transforming growth factor
Neurotrophin
Zdroj: The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(24)
ISSN: 1529-2401
Popis: Intrabrain transplantation of chromaffin cell aggregates of the Zuckerkandl's organ, an extra-adrenal paraganglion that has never been tested for antiparkinsonian treatment, induced gradual improvement of functional deficits in parkinsonian rats. These beneficial effects were related to long survival of grafted cells, striatal reinnervation, and enhancement of dopamine levels in grafted striatum. Grafted cells were not dopaminergics, but they expressed glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-β1. These factors were detected in the host striatal tissue, indicating that chromaffin cells secreted them after grafting. Because glial cell line-derived neurotrophic factor possesses neurorestorative properties over dopaminergic neurons, and transforming growth factor-β1is a cofactor that potentiates the neurotrophic actions of GDNF, functional regeneration was likely caused by the chronic trophic action of neurotrophic factors delivered by long-surviving grafted cells. This work should stimulate research on the clinical applicability of transplants of the Zuckerkandl's organ in Parkinson's disease.
Databáze: OpenAIRE
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