The effect of pentoxifylline on sperm motility, oocyte fertilization, embryo quality, and pregnancy outcome in an in vitro fertilization program
| Autor: | Nikos Kanakas, Areti Prapa, Katerina Voutsina, Katerina Arvaniti, Fotini Dimitriadou, Themis Mantzavinos, Demetrios Rizos |
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| Rok vydání: | 1995 |
| Předmět: |
Male
endocrine system medicine.medical_treatment Cleavage Stage Ovum Semen Fertilization in Vitro Biology Andrology fluids and secretions Human fertilization Pregnancy medicine Humans Prospective Studies Pentoxifylline Sperm motility In vitro fertilisation urogenital system Obstetrics and Gynecology medicine.disease Embryo Mammalian Sperm Pregnancy rate Reproductive Medicine Fertilization Sperm Motility Female Embryo quality |
| Zdroj: | Fertility and sterility. 63(4) |
| ISSN: | 0015-0282 |
| Popis: | Objective To study the effect of pentoxifylline on sperm motility, oocyte fertilization, embryo cleavage, and quality as well as pregnancy outcome on asthenospermic patients participating in an IVF program. Design Prospective randomized study. Setting Private IVF unit. Patients Ninety-seven couples, 24 of whom were repeating IVF. Two semen specimens were obtained from each patient and each specimen was divided equally into two parts, nontreated (control semen) and pentoxifylline-treated (treated semen). Main Outcome Measure Sperm progressive motility, oocyte fertilization. Results Overall and progressive motility did not differ significantly between the two semen specimens. There was a significant increase in the progressive motility of the pentoxifylline-treated semen compared with control semen. No significant difference was noticed between control and treated semen in fertilization rate, cleavage rate, embryo quality, and pregnancy rate. The percentage of patients who fertilized only with control semen (9.3%) was not significantly different from that of patients who fertilized only with treated semen (10.3%). Couples who were repeating IVF did not show significant difference in fertilization between the present study and previous attempts. Conclusion Our results showed that although the sperm progressive motility is improved after pentoxifylline treatment, it is doubtful whether this effect is of any clinical significance |
| Databáze: | OpenAIRE |
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