Early indicators of potential neoplasia produced in the rat forestomach by non-genotoxic agents: the importance of induced cellular proliferation
| Autor: | E. Lok, David B. Clayson, F. Iverson, E.A. Nera |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Rodent
Health Toxicology and Mutagenesis Cell Butylated Hydroxyanisole Biology chemistry.chemical_compound Stomach Neoplasms biology.animal Genetics medicine Animals Bioassay Inducer Molecular Biology Carcinogen Thyroid Anatomy Epithelium Rats medicine.anatomical_structure Acrylates chemistry Carcinogens Cancer research Propionates Butylated hydroxyanisole Cell Division Mutagens |
| Zdroj: | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 248:321-331 |
| ISSN: | 0027-5107 |
| DOI: | 10.1016/0027-5107(91)90065-v |
| Popis: | Forestomach neoplasia induced by the apparently non-genotoxic carcinogens, butylated hydroxyanisole and propionic acid, appears to arise by way of sustained high levels of cellular proliferation. Several other inducers of enhanced cellular proliferation, or the consequential indicidence of hyperplastic lesions, have been identified in the rodent forestomach bu the requisite carcinogenicity bioassays remain undone. In other tissues, such as the male rat kidney, the rodent thyroid follicuklar cell and the bladder epithelium, there is also evidence supporting the concept that sustained enhanced cellular proliferation may be an important early marker for non-genotoxic carcinogens. This reaction is, howerver, not likely to be the only marker necessary for the identification of non-genotoxic carcinogens. |
| Databáze: | OpenAIRE |
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