Animal models of human atherosclerosis: current progress
| Autor: | Alexey V. Deykin, Alexander N. Orekhov, Y.Y. Silaeva, A.V. Poznyak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Physiology Immunology Biophysics Ocean Engineering Inflammation Disease Review Disease pathogenesis Bioinformatics Biochemistry Rodents Animals Genetically Modified 03 medical and health sciences Mice 0302 clinical medicine Medicine Animals Humans General Pharmacology Toxicology and Pharmaceutics Genetically engineered model animals lcsh:QH301-705.5 lcsh:R5-920 business.industry General Neuroscience Disease progression Cell Biology General Medicine Atherosclerosis Animal models Rats Disease Models Animal 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Disease Progression Rabbits medicine.symptom lcsh:Medicine (General) business |
| Zdroj: | Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research, Vol 53, Iss 6 Brazilian Journal of Medical and Biological Research v.53 n.6 2020 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 53, Issue: 6, Article number: e9557, Published: 18 MAY 2020 |
| ISSN: | 1414-431X 0100-879X |
| Popis: | Atherosclerosis retains the leading position among the causes of global morbidity and mortality worldwide, especially in the industrialized countries. Despite the continuing efforts to investigate disease pathogenesis and find the potential points of effective therapeutic intervention, our understanding of atherosclerosis mechanisms remains limited. This is partly due to the multifactorial nature of the disease pathogenesis, when several factors so different as altered lipid metabolism, increased oxidative stress, and chronic inflammation act together leading to the formation and progression of atherosclerotic plaques. Adequate animal models are currently indispensable for studying these processes and searching for novel therapies. Animal models based on rodents, such as mice and rats, and rabbits represent important tools for studying atherosclerosis. Currently, genetically modified animals allow for previously unknown possibilities in modelling the disease and its most relevant aspects. In this review, we describe the recent progress made in creating such models and discuss the most important findings obtained with them to date. |
| Databáze: | OpenAIRE |
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