Lymphoepithelioma-Like Carcinoma of the Stomach with Epithelioid Granulomas
| Autor: | Toshihisa Tamura, Kosuke Makihara, Shigeo Yokoyama, Keiji Hirata, Kenji Kashima, Tetsuo Hamada, Yutaka Hirano, Tokihiko Fukuyama, Yasutaka Hachiya, Tatsuhiko Sako, Kozue Yamada |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Lymphoepithelioma-like carcinoma
Pathology medicine.medical_specialty Granuloma business.industry Stomach Gastroenterology Published: September 2010 medicine.disease_cause medicine.disease Epstein–Barr virus Metastasis medicine.anatomical_structure hemic and lymphatic diseases medicine Carcinoma Epstein-Barr virus lcsh:Diseases of the digestive system. Gastroenterology Lymph lcsh:RC799-869 business Lymph node |
| Zdroj: | Case Reports in Gastroenterology Case Reports in Gastroenterology, Vol 4, Iss 3, Pp 361-368 (2010) |
| ISSN: | 1662-0631 |
| Popis: | An 83-year-old Japanese man was admitted to our hospital for gastric adenocarcinoma mimicking a submucosal tumor in the gastric body. Considering his general condition, partial resection of the stomach and dissection of regional lymph nodes were performed; a dome-shaped tumor that was largely covered by normal mucosa and having a shallow central stellate ulcer was removed. Histopathologically, the carcinoma cell nests were surrounded by prominent lymphoid stroma. Sarcoid-like epithelioid granulomas were noted both in the tumor stroma and in the regional lymph node with metastasis. Epstein-Barr virus (EBV)-encoded RNA (EBER) in situ hybridization showed an intense and diffuse positive reaction in the carcinoma cells and no reaction in the surrounding gastric and lymphoid tissues. While the presence of lymphoid stroma is a characteristic finding in EBV-associated lymphoepithelioma-like carcinoma, sarcoid-like epithelioid granulomas might be associated with latent EBV infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|