The association between atrial fibrillation and in-hospital outcomes in chronic kidney disease patients with acute coronary syndrome: findings from the improving care for cardiovascular disease in China-acute coronary syndrome (CCC-ACS) project

Autor: Fengbo Xu, Jun Liu, Dong Zhao, Weijing Bian, Guoqin Wang, Ccc-Acs, Nan Ye, Hong Cheng, Na Yang, Yongchen Hao, Lijiao Yang, Jing Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
Cardiovascular disease in China
China
medicine.medical_specialty
Acute coronary syndrome
Time Factors
Databases
Factual
Population
Renal function
030204 cardiovascular system & hematology
Kidney
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Chronic kidney disease
medicine
Humans
Diseases of the circulatory (Cardiovascular) system
Hospital Mortality
030212 general & internal medicine
Renal Insufficiency
Chronic
Risk factor
education
Aged
Retrospective Studies
Aged
80 and over
education.field_of_study
business.industry
Incidence
Atrial fibrillation
Middle Aged
Prognosis
medicine.disease
Cardiac surgery
Hospitalization
RC666-701
Female
Cardiology and Cardiovascular Medicine
business
Glomerular Filtration Rate
Research Article
Kidney disease
Zdroj: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background Atrial fibrillation (AF) is the most common cardiac arrhythmia in patients with chronic kidney disease (CKD) and acute coronary syndrome (ACS). This study aimed to explore the frequency and impact of AF on clinical outcomes in CKD patients with ACS. Methods CKD inpatients with ACS between November 2014 and December 2018 were included based on the improving care for cardiovascular disease in China-ACS (CCC-ACS) project. Included patients were divided into an AF group and a non-AF group according to the discharge diagnosis. Multivariable logistic regression was used to adjust for potential confounders. Results A total of 16,533 CKD patients with ACS were included. A total of 1418 (8.6%) patients had clinically recognized AF during hospitalization, 654 of whom had an eGFR of 45 to 2, and 764 had an estimated glomerular filtration rate (eGFR) 2. Compared with the non-AF group, the AF group had a higher risk of in-hospital mortality [OR 1.250; 95% CI (1.001–1.560), P = 0.049] and major adverse cardiovascular events (MACEs) [OR 1.361; 95% CI (1.197–1.547), P 2, patients with eGFR 2 had a 1.512-fold increased risk of mortality and a 1.435-fold increased risk of MACEs. Conclusions AF was a risk factor affecting the short-term prognosis of ACS patients in the CKD population. Furthermore, the lower the eGFR, the higher the risk of in-hospital mortality and MACEs in CKD patients with ACS. Trial registry: Clinicaltrial.gov, NCT02306616. Registered 29 November 2014, https://clinicaltrials.gov/ct2/show/NCT02306616?term=NCT02306616&draw=2&rank=1
Databáze: OpenAIRE
Externí odkaz: