Performance of SNAPPE-II score in neonatal sepsis: an experience from a tertiary care center
| Autor: | Soma Sarkar, Moumita Samanta, Tapas Kumar Sabui, Nishith Kumar Pal, Chiranjib Biswas, Avijit Hazra, Avranil Goswami, Arijit Bhowmik |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
India Tertiary care Severity of Illness Index Sepsis Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Internal medicine Sick Newborn Medicine Humans Blood culture Prospective Studies Early onset medicine.diagnostic_test Negative blood culture Neonatal sepsis business.industry Infant Newborn medicine.disease Pediatrics Perinatology and Child Health Observational study Female Neonatal Sepsis business 030217 neurology & neurosurgery |
| Zdroj: | The Turkish journal of pediatrics. 62(2) |
| ISSN: | 2791-6421 |
| Popis: | Background and objectives The Score for Neonatal Acute Physiology II with Perinatal Extension (SNAPPE-II) is a vital tool for prognostication in newborns. The study was conducted with the hypothesis that the performance of the SNAPPE-II score might be affected by the presence of sepsis in newborns admitted with possible early onset septicemia and whether score performance varies between culture positive and culture negative sepsis. Methods The prospective observational study was conducted over a period of 1 year (January 2014 to January 2015) in neonates presenting with clinical suspicion of sepsis to the Sick Newborn Care Unit (SNCU) of a tertiary care hospital in Eastern India. Results SNAPPE-II score cut-off of ≥20 offered the highest sensitivity of 74.5% with specificity 48.3%, PPV 27.6% and NPV 87.7%. Comparison of mortality proportions between the two subgroups defined by this cut-off returned p= 0.005 with OR 3.47 (95% 1.40 to 8.64). No significant association was found between SNAPPE-II score and blood culture results; mean scores for culture positive (25.16 ± 15.6) and negative groups (24.49 ± 15.6) were comparable (p= 0.920). Conclusions At a cut-off value of ≥20 in presence of sepsis, SNAPPE-II score offers acceptable indices to predict mortality outcome. Prediction of outcome by SNAPPE-II score is not affected by positive or negative blood culture sepsis. |
| Databáze: | OpenAIRE |
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