Hippocampal–Prefrontal BDNF and Memory for Fear Extinction
| Autor: | Francisco Sotres-Bayon, Gregory J. Quirk, Luis E Rosas-Vidal, Fabricio H. Do-Monte |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Time Factors Immunocytochemistry Action Potentials Prefrontal Cortex Hippocampus Hippocampal formation Antibodies Extinction Psychological Rats Sprague-Dawley Memory Neurotrophic factors Conditioning Psychological Neural Pathways Animals Humans Prefrontal cortex Neurons Pharmacology Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor Fear social sciences Extinction (psychology) musculoskeletal system Recombinant Proteins humanities Sprague dawley Psychiatry and Mental health nervous system Practice Psychological Auditory Perception Original Article Psychology Neuroscience geographic locations |
| Zdroj: | Neuropsychopharmacology. 39:2161-2169 |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2014.64 |
| Popis: | Infusing brain-derived neurotrophic factor (BDNF) into the infralimbic (IL) prefrontal cortex is capable of inducing extinction. Little is known, however, about the circuits mediating BDNF effects on extinction or the extent to which extinction requires BDNF in IL. Using local pharmacological infusion of BDNF protein, or an antibody against BDNF, we found that BDNF in the IL, but not prelimbic (PL) prefrontal cortex, is both necessary and sufficient for fear extinction. Furthermore, we report that BDNF in IL can induce extinction of older fear memories (14 days) as well as recent fear memories (1 day). Using immunocytochemistry, we show that BDNF is increased in the ventral hippocampus (vHPC), but not IL or PL, following extinction training. Finally, we observed that infusing BDNF into the vHPC increased the firing rate of IL, but not PL neurons in fear conditioned rats. These findings indicate that an extinction-induced increase in BDNF within the vHPC enhances excitability in IL targets, thereby supporting extinction memories. |
| Databáze: | OpenAIRE |
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