Saliva specimen complements anal swab in assessing patients with COVID-19 for discharge from hospital
| Autor: | Xingzhe Liu, Jing Wang, Tingting Wu, Cheng Tian, Weisong Li, Shulin Zhang, Zhigang Song, Hongzhou Lu, Chenghao Qiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Saliva Epidemiology viruses Anal Canal Oropharynx Saliva specimen Nasopharynx Drug Discovery Medicine skin and connective tissue diseases False Negative Reactions conversion days virus diseases General Medicine Anal canal recurrent of viral detection Middle Aged Patient Discharge Infectious Diseases medicine.anatomical_structure COVID-19 Nucleic Acid Testing RNA Viral clinical specimen Female Severe acute respiratory syndrome coronavirus Research Article Adult medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Microbiology Young Adult stomatognathic system discharge Virology Internal medicine Humans Retrospective Studies business.industry SARS-CoV-2 Public health fungi COVID-19 Retrospective cohort study body regions Parasitology business |
| Zdroj: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| ISSN: | 2222-1751 |
| Popis: | Since December 2019, coronavirus disease 2019 (COVID-19) caused by SARS coronavirus 2 (SARS-CoV-2) has spread and threatens public health worldwide. The recurrence of SARS-CoV-2 RNA detection in patients after discharge from hospital signals a risk of transmission from such patients to the community and challenges the current discharge criteria of COVID-19 patients. A wide range of clinical specimens has been used to detect SARS-CoV-2. However, to date, a consensus has not been reached regarding the most appropriate specimens to use for viral RNA detection in assessing COVID-19 patients for discharge. An anal swab sample was proposed as the standard because of prolonged viral detection. In this retrospective longitudinal study of viral RNA detection in 60 confirmed COVID-19 patients, we used saliva, oropharyngeal/nasopharyngeal swab (O/N swab) and anal swab procedures from admission to discharge. The conversion times of saliva and anal swab were longer than that of O/N swab. The conversion time of hyper sensitive-CRP was the shortest and correlated with that of CT scanning and viral detection. Some patients were found to be RNA-positive in saliva while RNA-negative in anal swab while the reverse was true in some other patients, which indicated that false negatives were inevitable if only the anal swab is used for evaluating suitability for discharge. These results indicated that double-checking for viral RNA using multiple and diverse specimens was essential, and saliva could be a candidate to supplement anal swabs to reduce false-negative results and facilitate pandemic control. |
| Databáze: | OpenAIRE |
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