MS-681a, b, c and d, New Inhibitors of Myosin Light Chain Kinase from Myrothecium sp. KY6568. I. Characterization of Producing Strain and Production, Isolation and Biological Activities
| Autor: | Yutaka Saitoh, Yoji Ikuina, Satoshi Nakanishi, Hiroshi Yano, Katsuhiko Ando, Yuzuru Matsuda, Mayumi Yoshida |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Aminoisobutyric Acids Myosin light-chain kinase Strain (chemistry) Spermidine Biological activity Biology Enzyme chemistry Biochemistry Enzyme inhibitor Hypocreales Drug Discovery biology.protein Enzyme Inhibitors Peptides Protein kinase A Myosin-Light-Chain Kinase Protein kinase C Antibacterial agent |
| Zdroj: | The Journal of Antibiotics. 50:992-997 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.50.992 |
| Popis: | Novel compounds MS-681a, b, c and d were isolated from the culture broth of a fungal strain KY6568. The strain was identified as Myrothecium sp. from its morphological characteristics. MS-681a, b, c and d inhibited the activity of purified smooth muscle myosin light chain kinase with IC50 values of 0.11, 0.29, 0.095 and 0.26 microM, respectively. Cyclic AMP-dependent protein kinase, cyclic GMP-dependent protein kinase and protein kinase C were not inhibited at 100 microM by MS-681 compounds. |
| Databáze: | OpenAIRE |
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