Saponin surfactants used in drug delivery systems: A new application for natural medicine components
| Autor: | Zhixun Li, Lijing Lv, Yuyao Liao, Mengke Sheng, Yanshuang Shi, Qingsong Qu, Xinyuan Shi, Qing Zhou, Xingxing Dai, Jiaqi Yang |
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| Rok vydání: | 2021 |
| Předmět: |
Saponin
Pharmaceutical Science Nanotechnology 02 engineering and technology complex mixtures 030226 pharmacology & pharmacy Synergistic mechanism 03 medical and health sciences Surface-Active Agents 0302 clinical medicine Drug Delivery Systems parasitic diseases Amphiphile Natural medicine chemistry.chemical_classification Saponins musculoskeletal system 021001 nanoscience & nanotechnology carbohydrates (lipids) High surface chemistry Pharmaceutical Preparations Solubility Drug delivery Molecular mechanism 0210 nano-technology |
| Zdroj: | International journal of pharmaceutics. 603 |
| ISSN: | 1873-3476 |
| Popis: | Saponins are a group of compounds widely distributed in the plant kingdom. Due to their amphiphilic characteristic structure, saponins have high surface activity and self-assembly property and can be used as natural biosurfactants. Therefore, saponin has become a potential drug delivery system (DDS) carrier and has attracted the attention of many researchers. Increasing studies have found that when drugs combining with saponins, their solubility or bioavailability are improved. This phenomenon may be due to a synergistic mechanism and provides a potentially novel concept for DDS: saponins may be also used for carrier materials. This review emphasized the molecular characteristics and mechanism of saponins as carriers and the research on the morphology of saponin carriers. Besides, the article also introduced the role and application of saponins in DDS. Although there are still some limitations with the application of saponins such as cost, applicability, and hemolysis, the development of technology and in-depth molecular mechanism research will provide saponins with greater application prospects as DDS carriers. |
| Databáze: | OpenAIRE |
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