Association of synapsin III gene with adult attention deficit hyperactivity disorder

Autor: Mehmet Emin Erdal, Hasan Herken, Tuba Gökdoğan Edgünlü, Ayse Nur Inci Kenar
Přispěvatelé: MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Edgünlü, Tuba
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
genomic DNA
genetic association
genotype
genetic analysis
Hyperactivity disorder
Polymorphism (computer science)
Age of Onset
comparative study
Genetics
Dopaminergic
allele
article
General Medicine
phosphoprotein
unclassified drug
female
priority journal
Adult
attention deficit disorder
Biology
gene frequency
behavioral disciplines and activities
Polymorphism
Single Nucleotide
Young Adult
mental disorders
medicine
Attention deficit hyperactivity disorder
Humans
controlled study
Genetic Predisposition to Disease
human
Allele
Molecular Biology
Gene
Allele frequency
Alleles
Genetic Association Studies
Case-control study
Cell Biology
medicine.disease
Synapsins
major clinical study
DNA polymorphism
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Age of onset
synapsin III
adult disease
Popis: It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD. © Copyright 2013, Mary Ann Liebert, Inc. 2013.
Databáze: OpenAIRE
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