Overcome the barriers of the skin: exosome therapy
| Autor: | Donggu Kang, HoJun Jeon, Yoon Bum Lee, Gi Hoon Yang, Eunjeong Choi, Hyo Jin Kang, Hi Jin You, Sang Hyun An, Yoonju Nam, KyoungHo Lee |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Future perspective integumentary system Chemistry Regeneration (biology) Biomedical Engineering Medicine (miscellaneous) Review Biomarker Skin defects Exosomes Exosome Microvesicles Cell biology Biomaterials 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Potential biomarkers Medical technology Ceramics and Composites Skin treatment R855-855.5 |
| Zdroj: | Biomaterials Research Biomaterials Research, Vol 25, Iss 1, Pp 1-13 (2021) |
| ISSN: | 2055-7124 |
| Popis: | Exosomes are nano-sized cargos with a lipid bilayer structure carrying diverse biomolecules including lipids, proteins, and nucleic acids. These small vesicles are secreted by most types of cells to communicate with each other. Since exosomes circulate through bodily fluids, they can transfer information not only to local cells but also to remote cells. Therefore, exosomes are considered potential biomarkers for various treatments. Recently, studies have shown the efficacy of exosomes in skin defects such as aging, atopic dermatitis, and wounds. Also, exosomes are being studied to be used as ingredients in commercialized skin treatment products. In this review, we discussed the need for exosomes in skin therapy together with the current challenges. Moreover, the functional roles of exosomes in terms of skin treatment and regeneration are overviewed. Finally, we highlighted the major limitations and the future perspective in exosome engineering. |
| Databáze: | OpenAIRE |
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