Mortality prediction in systemic lupus erythematosus patients with pulmonary infection
| Autor: | Juan Ji, Jing Li, Zhifeng Gu, Zhanyun Da, Zhimin Lu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Time Factors Adolescent Lymphocyte Logistic regression Risk Assessment 03 medical and health sciences Young Adult 0302 clinical medicine Rheumatology Risk Factors Internal medicine Lymphopenia medicine Albuminuria Humans Lupus Erythematosus Systemic 030212 general & internal medicine Hospital Mortality Respiratory Tract Infections Retrospective Studies 030203 arthritis & rheumatology Aged 80 and over Receiver operating characteristic business.industry Odds ratio Complement C3 Middle Aged Prognosis Hospitalization medicine.anatomical_structure Cohort Female medicine.symptom Low Complement business Biomarkers |
| Zdroj: | International journal of rheumatic diseases. 22(6) |
| ISSN: | 1756-185X |
| Popis: | OBJECTIVE The impact of pulmonary infection (PI) on mortality of patients with systemic lupus erythematosus (SLE) has been established. Nevertheless, the effect of risk factors in mortality remains controversial. The objective of this study is to determine the risk factors of short-term mortality among SLE patients with PI. METHOD The clinical data of 54 SLE patients with 59 episodes of PI who were hospitalized from January 2013 to May 2018 was retrospectively analyzed. Demographic data, clinical features, and outcomes were collected. Logistic regression analysis was carried out to determine the independent predictors of 60-day mortality during hospitalization. We used receiver operating characteristics (ROC) curves to verify the indices as mortality predictors in the study patients. RESULTS There were a total of 54 patients with 59 episodes of PI. There were 12 deaths during hospitalization. In multivariate analysis, 24-hour urinary protein (24h-PRO) (odds ratio [OR]: 2.713, 95% CI: 1.234-5.965, P = 0.013), peripheral lymphocyte count (OR: 0.066, 95% CI: 0.005-0.887, P = 0.040), and serum complement 3 level (C3) (OR: 0.097, 95% CI: 0.010-0.954, P = 0.045) were associated with mortality among our cohort of SLE patients with PI. ROC curve values were 0.818 for lymphocyte count (95% CI: 0.696-0.907, P = 0.001), 0.894 for 24h-PRO (95% CI: 0.786-0.959, P |
| Databáze: | OpenAIRE |
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