Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases
| Autor: | Mehmet Demirci, Reyhan Caliskan, Suat Saribas, Pelin Yuksel, Omer Uysal, Bekir Kocazeybek, Yagız Meric Altun, Asli Vatan, Tevhide Ziver, Pari Sohrabi, Zafer Habip, Harika Oyku Dinc |
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| Přispěvatelé: | YÜKSEL MAYDA, PELİN |
| Rok vydání: | 2017 |
| Předmět: |
SOHRABİ P.
Habip Z. Saribas S. Vatan A. Dinc H. O. Altun Y. M. ZİVER T. Caliskan R. Demirci M. Uysal O. et al. -Neopterin and soluble CD14 (sCD14) levels as immunoactivation markers in aHBc-only cases- FUTURE VIROLOGY cilt.12 ss.409-419 2017 biology business.industry CD14 Significant difference Neopterin 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Chronic hepatitis chemistry Virology Healthy control Immunology biology.protein Medicine 030211 gastroenterology & hepatology Antibody business Hepatitis b core |
| Popis: | Aim: Isolated hepatitis B core antibodies (aHBc)-only pattern complicates the diagnosis of HBV infections. We evaluated neopterin and sCD14 levels in HBV infections. Methods: aHBc-only (n: 102), healthy control (healthy control group [HCG], n: 100), and chronic hepatitis (CHB) groups (n: 70) were investigated. Competitive and sandwich ELISA were used. Results: The mean neopterin levels were significantly lower in the aHBc-only group than those in the CHB group (p = 0.0001). No significant difference was found between the aHBc-only group and the HCG (p = 0.854). The mean sCD14 levels were lower in the aHBc-only group than those in the CHB group (p = 0.0001), but no significant difference was found between the aHBc-only group and HCG (p = 0.402). No significant difference was detected between aHBc-only and HCG for mean sCD14 (p = 0.402) and neopterin levels (p = 0.854). Conclusion: These two biomarkers are not useful for diagnosing the aHBc only pattern. |
| Databáze: | OpenAIRE |
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