Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing

Autor:	Navarro, Maria N., Gómez de las Heras, Manuel M., Mittelbrunn, Maria
Přispěvatelé:	Ministerio de Ciencia e Innovación (España), European Research Council, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Investigación Hospital 12 de Octubre, Fundación Ramón Areces, Banco Santander
Rok vydání:	2021
Předmět:	lymphocytes 0301 basic medicine Autoimmunity Inflammation CD38 Nicotinamide adenine dinucleotide Cofactor 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system NAD+ medicine Sirtuins Pharmacology Experimental autoimmune encephalomyelitis biology T Cells Adenosine diphosphate ribose Immunity Metabolism NAD 3. Good health Cell biology Ageing 030104 developmental biology chemistry inflammation biology.protein NAD+ kinase medicine.symptom Energy Metabolism 030217 neurology & neurosurgery
Zdroj:	British Journal of Pharmacology Digital.CSIC. Repositorio Institucional del CSIC instname
ISSN:	0007-1188
DOI:	10.1111/bph.15477
Popis:	Metabolism is dynamically regulated to accompany immune cell function, and altered immunometabolism can result in impaired immune responses. Concomitantly, the pharmacological manipulation of metabolic processes offers an opportunity for therapeutic intervention in inflammatory disorders. The nicotinamide adenine dinucleotide (NAD+) is a critical metabolic intermediate that serves as enzyme cofactor in redox reactions, and is also used as a co-substrate by many enzymes such as sirtuins, adenosine diphosphate ribose transferases and synthases. Through these activities, NAD+ metabolism regulates a broad spectrum of cellular functions such as energy metabolism, DNA repair, regulation of the epigenetic landscape and inflammation. Thus, the manipulation of NAD+ availability using pharmacological compounds such as NAD+ precursors can have immune-modulatory properties in inflammation. Here, we discuss how the NAD+ metabolism contributes to the immune response and inflammatory conditions, with a special focus on multiple sclerosis, inflammatory bowel diseases and inflammageing Spanish Ministry of Science and Innovation (PID2019-110511RB-I00) to M.N.N, and the H2020-EU.1.1, European Research Council (ERC-2016-StG 715322-EndoMitTalk), Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI19/855) to M.M, Fondo Europeo de Desarrollo Regional (FEDER) to M.M and M.N.N. M.M.GH was funded by the Spanish Ministry of Science, Innovation and Universities (FPU19/02576). M.M. is supported by the Miguel Servet program (CPII19/00014, Fundación de Investigación del Hospital 12 de Octubre). Institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSO are also acknowledged.
Databáze:	OpenAIRE
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