Clinical Value of Whole Blood Procalcitonin Using Point of Care Testing, Quick Sequential Organ Failure Assessment Score, C-Reactive Protein and Lactate in Emergency Department Patients with Suspected Infection
| Autor: | Eu-Sun Lee, Young-Duck Cho, Bosun Shim, Sung-Jun Park, Jung-Youn Kim, Young-Hoon Yoon, Sung-Hyuk Choi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Point-of-care testing lcsh:Medicine Article Procalcitonin 03 medical and health sciences 0302 clinical medicine Internal medicine parasitic diseases medicine 030212 general & internal medicine bacteremia Whole blood biology business.industry Sequential organ failure assessment C-reactive protein lcsh:R 030208 emergency & critical care medicine General Medicine Emergency department medicine.disease bacterial infections and mycoses mortality point-of-care testing Bacteremia Clinical value biology.protein business hormones hormone substitutes and hormone antagonists procalcitonin |
| Zdroj: | Journal of Clinical Medicine Volume 8 Issue 6 Journal of Clinical Medicine, Vol 8, Iss 6, p 833 (2019) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm8060833 |
| Popis: | We investigated the clinical value of whole blood procalcitonin using point of care testing, quick sequential organ failure assessment score, C-reactive protein and lactate in emergency department patients with suspected infection and assessed the accuracy of the whole blood procalcitonin test by point-of-care testing. Participants were randomly selected from emergency department patients who complained of a febrile sense, had suspected infection and underwent serum procalcitonin testing. Whole blood procalcitonin levels by point-of-care testing were compared with serum procalcitonin test results from the laboratory. Participants were divided into two groups&mdash those with bacteremia and those without bacteremia. Sensitivity, specificity, positive predictive value, negative predictive value of procalcitonin, lactate and Quick Sepsis-related Organ Failure Assessment scores were investigated in each group. Area under receiving operating curve of C-reactive protein, lactate and procalcitonin for predicting bacteremia and 28-day mortality were also evaluated. Whole blood procalcitonin had an excellent correlation with serum procalcitonin. The negative predictive value of procalcitonin and lactate was over 90%. Area under receiving operating curve results proved whole blood procalcitonin to be fair in predicting bacteremia or 28-day mortality. In the emergency department, point-of-care testing of whole blood procalcitonin is as accurate as laboratory testing. Moreover, procalcitonin is a complementing test together with lactate for predicting 28-days mortality and bacteremia for patients with suspected infection. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |