INDOLENT, NONPROGRESSIVE, MULTIFOCAL CHOROIDAL LESIONS
| Autor: | Lee M. Jampol, Eduardo Cunha de Souza, William J Carroll, Antonio Marcelo Barbante Casella, Heather N Shelsta, Mark J. Daily, Gábor Gy Deák |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Indocyanine Green Male Pathology medicine.medical_specialty Malignancy Multimodal Imaging Asymptomatic Lymphocytic Infiltrate Intraocular Lymphoma Humans Medicine Fluorescein Angiography Coloring Agents Aged Retrospective Studies business.industry Choroid Neoplasms General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging Birdshot chorioretinopathy eye diseases Lymphoma Ophthalmology medicine.anatomical_structure Etiology Female sense organs Sarcoidosis Choroid medicine.symptom Tomography X-Ray Computed business Follow-Up Studies |
| Zdroj: | Retina. 40:1980-1987 |
| ISSN: | 0275-004X |
| DOI: | 10.1097/iae.0000000000002865 |
| Popis: | Purpose In 2012, four patients with multiple asymptomatic, indolent, unilateral, choroidal lesions were described. We suspected benign-behaving lymphocytes infiltrating the choroid. This article expands the number of patients and duration of follow-up and speculates further on the etiology. Although histopathologic confirmation of these lesions is still unknown, the natural course of these patients is excellent and should be distinguished from aggressive choroidal lymphoma. Methods To qualify for the study, the patients had to meet the following criteria: 1) Patients collected had asymptomatic choroidal infiltrates as demonstrated in the figures; 2) absence of vitreous cells; 3) no evidence of concomitant systemic malignancy; 4) no systemic inflammatory diseases, including sarcoidosis; 5) no birdshot chorioretinopathy; 6) no conjunctival or orbital lesions; and 7) advanced multimodal imaging and clinical follow-up were performed. Results There were 11 eyes of 11 patients seen. Follow-up ranged from 4 months to 12 years and 1 month (mean 50.2 months; median 24 months). Systemic workup was unrevealing. No patients in this cohort developed systemic, conjunctival, orbital, or vitreoretinal lymphoma or inflammatory disease. No patients developed symptoms or vision loss. Conclusion This entity is an indolent choroidal infiltrative disease. It resembles some cases of choroidal lymphoma and may represent an indolent lymphocytic infiltrate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|