Prevalence of multidrug efflux pump requiring ciprofloxacin, ofloxacin and pefloxacin as substrates, among clinical isolates of Pseudomonas aeruginosa
| Autor: | J. O. Okonkwo, I. N. Ibeh, U. E. Airueghionmon, R. Omoregie, HO Ogefere, D. J. U. Airueghionmon |
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| Rok vydání: | 2007 |
| Předmět: |
Drug
Reserpine Efflux pump Pseudomonas aeruginosa Chemistry media_common.quotation_subject Pseudomones aeruginosa lcsh:QR1-502 medicine.disease_cause Applied Microbiology and Biotechnology lcsh:Microbiology Pefloxacin Microbiology Ciprofloxacin medicine Efflux Ofloxacin Fluoroquinolones media_common medicine.drug |
| Zdroj: | Malaysian Journal of Microbiology, Vol 3, Iss 2, Pp 37-40 (2007) |
| ISSN: | 2231-7538 |
| DOI: | 10.21161/mjm.01307 |
| Popis: | Forty two consecutive clinical isolates of Pseudomonas aeruginosa were screened for the presence of reserpine inhibited multidrug (MDR) efflux pump, utilizing ciprofloxacin ofloxacin and/or pefloxacin as substrates, by determining the minimum inhibitory concentration in the presence and absence of 100 mg/L reserpine. The result showed that 50% of the Pseudomonas aeruginosa isolates possessed reserpine inhibited MDR efflux pump. MDR efflux pump requiring ofloxacin (40.48%) were significantly (p |
| Databáze: | OpenAIRE |
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