Increased autoreactive T cell frequency in tuberculous patients
| Autor: | G. Lombardi, P. Del Porto, M. S. Gilardini Montani, Orsola Pugliese, Guido Antonelli, V. Colizzi, F. Del Gallo, Enza Piccolella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1990 |
| Předmět: |
T-Lymphocytes
T cell Immunology Lymphocyte Activation Tuberculin Epitope Epitopes Leukocyte Count Antigen Humans Immunology and Allergy Medicine Cytotoxic T cell Interferon gamma Tuberculosis Pulmonary Cells Cultured MHC class II biology business.industry Stem Cells Histocompatibility Antigens Class II Mycobacterium tuberculosis General Medicine T lymphocyte Clone Cells medicine.anatomical_structure Peripheral blood lymphocyte biology.protein Lymphocyte Culture Test Mixed business medicine.drug |
| Popis: | The development of putative self-MHC-reactive T cells and their precursor frequency was estimated in peripheral blood lymphocyte cultures stimulated in vitro with PPD. The role of foreign antigen in the generation of self-MHC-reactive T cells in vivo was analyzed by comparing the frequency of autoreactive T cells in the peripheral blood of tuberculous patients with that observed in healthy individuals. It was found that PPD in vitro and Mycobacterium tuberculosis infection in vivo increased substantially the generation of autoreactive T cells. Autoreactive T cell clones were shown (1) to recognize self MHC class II products; (2) to release gamma interferon in the absence of exogenous antigen, and (3) to express autocytotoxic activity. All these findings suggest that self-MHC-reactive T cells may be involved in the inflammatory response to M. tuberculosis. |
| Databáze: | OpenAIRE |
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