Comparison of Enflurane and Propofol in Electroconvulsive Therapy, a Randomized Crossover Open Preliminary Study on Seizure Duration and Anaesthetic Recovery
| Autor: | Nimet Senoglu, Hafize Öksüz, Huseyin Yildiz, Ismail Coskuner, Zafer Dogan, Elif Biter, Nadiye Ugur |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
Male Time Factors Sinus tachycardia Nausea General Anesthesia General ANESTESIA: Geral medicine.medical_treatment Sinus bradycardia TRATAMENTO Electroencephalography TRATAMIENTO Enflurane Young Adult Electroconvulsive therapy Seizures medicine Humans General anaesthesia Prospective Studies Electroconvulsive Therapy Propofol Volátil enflurano Cross-Over Studies medicine.diagnostic_test business.industry Middle Aged ANESTÉSICOS: Venoso propofol Anesthesiology and Pain Medicine ANESTESIA: General Anesthesia Anesthesia Recovery Period Anesthetics Inhalation Female Therapy medicine.symptom business Anesthetics Intravenous medicine.drug |
| Zdroj: | Brazilian Journal of Anesthesiology. (5):582-590 |
| ISSN: | 0034-7094 |
| DOI: | 10.1016/S0034-7094(11)70069-1 |
| Popis: | Dogan Z, Senoglu N, Yildiz H, Coskuner I, Ugur N, Biter E, Oksuz H - Comparison of Enflurane and Propofol in Electroconvulsive Therapy, a Randomized Crossover Open Preliminary Study on Seizure Duration and Anaesthetic Recovery. Background and objectives: Electroconvulsive therapy (ECT) is commonly used for treatment of depression, mania and affective disorders. Anaesthetics for general anaesthesia during ECT should have rapid onset, rapid emerge, not interfere with seizure activity and not shorten seizure duration. The aim of this study is to compare effects of enflurane, a pro-convulsive anaesthetic agent, and propofol on seizure durations, postictal suppression index and recovery times during electroconvulsive therapy. Methods: Unpremedicated subjects were divided into two groups according to induction of anaesthesia. Patients were induced for ECT with 5% enflurane in group E and 1.2 mg.kg(-1) propofol in group P until loss of consciousness. The durations of electroencephalogram (EEG) and motor seizures, postictal suppression index, time to spontaneous breathing, duration of eye opening, and obeying commands were recorded. Results: There was no statistically significant difference between the groups regarding motor and EEG seizure times and postictal suppression index on the EEG records. Recovery times (times of starting spontaneous breathing, eye opening, and obeying command) were significantly shorter in group E compared to group P. No nausea or vomiting were observed and no ECG abnormality was noted except transient sinus bradycardia and sinus tachycardia. Conclusions: Although sufficient seizure for the treatment was provided during enflurane anaesthesia, any additional benefit was not revealed regarding seizure times or postictal suppression index when compared to propofol anaesthesia. On the other hand, recovery times after enflurane anaesthesia were shorter than propofol anaesthesia. However, there is still a need for further study in different ETCO(2) levels. |
| Databáze: | OpenAIRE |
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