Antibiotic Consumption and Resistance during a 3-Year Period in Sicily, Southern Italy
| Autor: | Pasquale Cananzi, Claudia La Mastra, Annalisa Quattrocchi, Andrea Maugeri, Giuseppe Murolo, Laura Sessa, Alessandro Oteri, Antonella Agodi, Maria Clara La Rosa, Guido Basile, Martina Barchitta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Health Toxicology and Mutagenesis Cephalosporin Antibiotics lcsh:Medicine Pharmacy Article 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Environmental health health services administration medicine Escherichia coli Humans Public Health Surveillance 030212 general & internal medicine defined daily dose Sicily Consumption (economics) 0303 health sciences 030306 microbiology business.industry Public health lcsh:R public health Public Health Environmental and Occupational Health Drug Resistance Microbial resistance rates Drug Utilization indicators Anti-Bacterial Agents Penicillin Klebsiella pneumoniae Defined daily dose Carbapenems surveillance business medicine.drug Fluoroquinolones |
| Zdroj: | International Journal of Environmental Research and Public Health Volume 16 Issue 13 International Journal of Environmental Research and Public Health, Vol 16, Iss 13, p 2253 (2019) |
| Popis: | Antimicrobial resistance (AMR) is one of the biggest issues facing global public health. In 2017, Italy adopted its first National Action Plan on Antimicrobial Resistance 2017&ndash 2020, which works through the synergy between national, regional, and local levels. In the framework of a Regional Action Plan on healthcare-associated infections and AMR prevention, the Sicilian Health Authority of the Sicilian Region, Southern Italy, has implemented a surveillance system of antibiotic consumption in hospitals, in the community, and of resistance rates (RRs) in hospital settings. Data on antibiotic consumption and on antibiotic RRs have been collected from 2015 to 2017 from pharmacies and laboratories of participating hospitals and from community, respectively. Data on antibiotic consumption showed that the most consumed antibiotics in hospitals were fluoroquinolones in 2015, penicillin in 2016, and beta-lactams in 2017. From 2015 to 2017, data on Klebsiella pneumoniae showed significant increasing RRs to all antibiotic classes, except to carbapenems. RRs of third-generation cephalosporins and carbapenems Escherichia coli showed significant decreasing trends. RRs of the other microorganisms did not change significantly during the study period. The results from the present study show that in Sicily, the use of antibiotics and RRs for selected microorganisms are at a high level. Immediate strategies are needed to decrease the inappropriate usage of antibiotics and control the spread of AMR. |
| Databáze: | OpenAIRE |
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