Short-term memory deficits correlate with hippocampal-thalamic functional connectivity alterations following acute sleep restriction

Autor: Shao Yongcong, Ye Enmao, Li Chengyang, Meng Qingqing, Liu Jiajia, Qi Jianlin, Chang Haisheng, Zhang Xi, Huang Daqing, Wang Jin
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Adolescent
Cognitive Neuroscience
Rest
Hippocampus
Short-term memory
Hippocampal formation
Neuropsychological Tests
Functional Laterality
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Young Adult
0302 clinical medicine
Thalamus
Neural Pathways
medicine
Humans
Radiology
Nuclear Medicine and imaging
Effects of sleep deprivation on cognitive performance
Neuroscience of sleep
Sleep restriction
Brain Mapping
Memory Disorders
Cross-Over Studies
Recognition
Psychology
Magnetic Resonance Imaging
Psychiatry and Mental health
Sleep deprivation
030104 developmental biology
Memory
Short-Term
Neurology
Superior frontal gyrus
Sleep Deprivation
Neurology (clinical)
medicine.symptom
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain imaging and behavior. 11(4)
ISSN: 1931-7565
Popis: Acute sleep restriction heavily influences cognitive function, affecting executive processes such as attention, response inhibition, and memory. Previous neuroimaging studies have suggested a link between hippocampal activity and short-term memory function. However, the specific contribution of the hippocampus to the decline of short-term memory following sleep restriction has yet to be established. In the current study, we utilized resting-state functional magnetic resonance imaging (fMRI) to examine the association between hippocampal functional connectivity (FC) and the decline of short-term memory following total sleep deprivation (TSD). Twenty healthy adult males aged 20.9 ± 2.3 years (age range, 18–24 years) were enrolled in a within-subject crossover study. Short-term memory and FC were assessed using a Delay-matching short-term memory test and a resting-state fMRI scan before and after TSD. Seed-based correlation analysis was performed using fMRI data for the left and right hippocampus to identify differences in hippocampal FC following TSD. Subjects demonstrated reduced alertness and a decline in short-term memory performance following TSD. Moreover, fMRI analysis identified reduced hippocampal FC with the superior frontal gyrus (SFG), temporal regions, and supplementary motor area. In addition, an increase in FC between the hippocampus and bilateral thalamus was observed, the extent of which correlated with short-term memory performance following TSD. Our findings indicate that the disruption of hippocampal–cortical connectivity is linked to the decline in short-term memory observed after acute sleep restriction. Such results provide further evidence that support the cognitive impairment model of sleep deprivation.
Databáze: OpenAIRE
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