Difference between young and old patients in characteristics of leukemic cells: older patients have cells growing excessively in vitro, with low antigenicity despite high HLA-DR antigens
Autor: | Bertil Lindblom, Peter Reizenstein, Robert Hast, Claudio Ogier, Nicos Giannoulis, Ann-Marie Sjögren |
---|---|
Rok vydání: | 1984 |
Předmět: |
Adult
Cytotoxicity Immunologic Male Antigenicity Adolescent Cell Colony-Forming Units Assay Antigen Antigens Neoplasm medicine Humans HLA-DR Antigen Aged Acute leukemia business.industry Stem Cells Age Factors Histocompatibility Antigens Class II Hematology HLA-DR Antigens Middle Aged medicine.disease In vitro Leukemia Leukemia Myeloid Acute Allogeneic Lymphocyte medicine.anatomical_structure Immunology Neoplastic Stem Cells Female Lymphocyte Culture Test Mixed business |
Zdroj: | American journal of hematology. 16(2) |
ISSN: | 0361-8609 |
Popis: | Fifty-six patients with acute, non-lymphatic leukemia in the initial phase were studied. The poor prognostic signs were excessive in vitro growth, many HLA-DR-positive cells, or a low ratio of leukemic cell antigenicity to HLA-DR positivity and age. The cells from older patients formed more clusters (P less than 0.05), and they had less capacity to stimulate normal allogeneic lymphocytes (P less than 0.05) than those from younger patients. Cells forming many clusters also were more often (P less than 0.01) HLA-DR-positive than those forming few clusters. It is suggested that the prognosis in old patients with acute leukemia is poor in part because their leukemic cells have characteristics different from those of young patients. |
Databáze: | OpenAIRE |
Externí odkaz: |