Body composition and lung function in children with cystic fibrosis and meconium ileus
| Autor: | Artemis Doulgeraki, George P. Chrousos, Athanasios G. Kaditis, Argyri Petrocheilou, S. Doudounakis, Glykeria Petrocheilou |
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| Rok vydání: | 2017 |
| Předmět: |
Male
musculoskeletal diseases Spirometry medicine.medical_specialty Adolescent Cystic Fibrosis Meconium Ileus 030209 endocrinology & metabolism Cystic fibrosis Gastroenterology Young Adult 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Bone Density Forced Expiratory Volume Internal medicine Odds Ratio medicine Humans Child Lung Routine care Lung function Retrospective Studies Bone mineral medicine.diagnostic_test business.industry Malnutrition Mean age Total body medicine.disease Logistic Models Endocrinology 030228 respiratory system Pediatrics Perinatology and Child Health Body Composition Female business |
| Zdroj: | European Journal of Pediatrics. 176:737-743 |
| ISSN: | 1432-1076 0340-6199 |
| DOI: | 10.1007/s00431-017-2906-z |
| Popis: | The aim of this study was to explore whether history of meconium ileus (MI) at birth in children and adolescents with cystic fibrosis (CF) adversely affects body composition and lung function in later life. Data of children and adolescents with CF who underwent spirometry and DXA as part of their routine care were analyzed. Associations between MI (explanatory variable) and areal bone mineral density (total body less head—TBLH aBMD), lean tissue mass (LTM), and fat mass (FM) (outcomes) were assessed using general linear models. Potential relationships of TBLH aBMD, LTM, and FM with FEV1 (additional outcome) were also explored. One hundred and one subjects with CF (mean age 14 ± 3 years) were included, 19 (18.8%) of whom had history of MI. Negative associations were demonstrated between history of MI and FEV1 (P = 0.04), TBLH aBMD (P = 0.03), and FM (P < 0.01) but not between history of MI and LTM (P = 0.07) after adjustment for other variables. Lung function was positively associated with TBLH aBMD (P < 0.01) and LTM (P = 0.02) but not with FM (P = 0.20). |
| Databáze: | OpenAIRE |
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