The Role of the NKG2D in Vitiligo
| Autor: | Lourdes Plaza-Rojas, José A. Guevara-Patiño |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cytotoxicity
Immunologic vitiligo T cell Immunology T cells Autoimmunity Skin Pigmentation chemical and pharmacologic phenomena Vitiligo Review Biology Melanocyte CD8-Positive T-Lymphocytes medicine.disease_cause NKG2D Hsp70 Depigmentation medicine Immunology and Allergy Animals Humans oxidative stress Skin Correction hemic and immune systems RC581-607 medicine.disease Cell biology Cytolysis medicine.anatomical_structure Cellular Microenvironment NK Cell Lectin-Like Receptor Subfamily K horror autotoxicus Melanocytes Immunologic diseases. Allergy medicine.symptom Oxidative stress Signal Transduction |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| Popis: | Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and enhance TCR signaling, we examine how melanocyte stress leads to the expression of ligands that are recognized by the activating receptor NKG2D, and how its signaling results in the turning of T cells against self (melanocyte suicide by proxy). We also discuss how this initiation phase is followed by T cell perpetuation, as NKG2D signaling results in self-sustained long-lasting T cells, with improved cytolytic properties. |
| Databáze: | OpenAIRE |
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