Beta 3 subunit of G-protein and its influence on autonomic nervous system in patients with vasovagal syncope
| Autor: | Peter Mitro, M Simurda, V Habalova, P Murin, E Muller, L Evin |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Economics and Econometrics medicine.medical_specialty Hemodynamics Blood Pressure Autonomic Nervous System Tilt table test Heart Rate Tilt-Table Test Internal medicine Heart rate Syncope Vasovagal Materials Chemistry Media Technology Humans Medicine Heart rate variability Prospective Studies Prospective cohort study Vasovagal syncope Aged Polymorphism Genetic medicine.diagnostic_test business.industry Forestry Middle Aged medicine.disease Heterotrimeric GTP-Binding Proteins Autonomic nervous system Blood pressure Cardiology Female business |
| Zdroj: | Bratislava Medical Journal. 116:142-147 |
| ISSN: | 1336-0345 |
| DOI: | 10.4149/bll_2016_027 |
| Popis: | OBJECTIVES The aim of this prospective study was to investigate the impact of genetic polymorphisms of β3 subunit of G-protein on the occurrence of vasovagal syncope, hemodynamic parameters and heart rate variability during head-up tilt test (HUT). BACKGROUND G-proteins play an important role in the intracellular transmission of impulses in cardiovascular autonomic reflexes. METHODS In 157 patients with suspected vasovagal syncope HUT was performed. Ninety-one patients (38 men, 53 women, mean age 48 ± 17 years) had positive HUT. Control group consisted of 109 subjects (69 men, 40 women, mean age 37 ± 16 years) with no history of syncope. Results of HUT, hemodynamic parameters and LF, HF, LF/HF, SDNN, RMSSD parameters of heart rate variability were compared in patients with different genotypes. C825T polymorphism of β3 subunit of G-protein was determined in the study subjects. RESULTS There was no significant difference in the distribution of genotypes between patients and control group. Also, there was no significant difference in hemodynamic parameters. A statistically significant difference was found between genotypes in LF/HF in the early HUT (mean rank CC: 48.68 vs CT: 35.51 vs TT: 34.14; p = 0.039) and at RMSSD at the time of syncope (mean rank CC: 32.38 vs CT: 42.74 vs TT: 18.50; p = 0.026). CONCLUSIONS In this study, the relation of C825T polymorphism of β3 subunit of G-protein to vasovagal syncope was not documented (Tab. 2, Fig. 4, Ref. 37). |
| Databáze: | OpenAIRE |
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