Antiviral Potential of Naphthoquinones Derivatives Encapsulated within Liposomes
| Autor: | Gustavo B. da Silva, Rosa Bellavita, Izabel Christina Nunes de Palmer Paixão, Stefania Galdiero, Viveca Giongo, S.G. De-Simone, Camilly P. Pires De Melo, Annarita Falanga |
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| Přispěvatelé: | Giongo, Viveca, Falanga, Annarita, De Melo, Camilly P Pire, da Silva, Gustavo B, Bellavita, Rosa, De-Simone, Salvatore G, Paixão, Izabel C, Galdiero, Stefania |
| Rok vydání: | 2021 |
| Předmět: |
liposome drug carrier
Cell Survival Pharmaceutical Science herpes simplex virus type 1 Herpesvirus 1 Human Pharmacology Chlorocebus aethiop Antiviral Agents Article Analytical Chemistry chemistry.chemical_compound QD241-441 Immune system Naphthoquinone In vivo Phosphatidylcholine Chlorocebus aethiops Drug Discovery medicine Animals Humans Physical and Theoretical Chemistry Drug Carrier Vero Cells Cells Cultured Antiviral Agent Drug Carriers Liposome Molecular Structure Animal Chemistry nanoparticle Organic Chemistry aminomethylnaphthoquinone medicine.disease Cold sore aminomethylnaphthoquinones Chemistry (miscellaneous) Liposomes Vero Cell Nanoparticles Molecular Medicine Amine gas treating Drug carrier Human Naphthoquinones |
| Zdroj: | Molecules Volume 26 Issue 21 Molecules, Vol 26, Iss 6440, p 6440 (2021) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules26216440 |
| Popis: | HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold sores up to 10 days of infection, blindness and encephalitis caused by HSV-1 affecting immunocompetent and immunosuppressed individuals. The severe effects derive from co-evolution with the host, resulting in immune evasion mechanisms, including latency and growing resistance to acyclovir and derivatives. An efficient alternative to controlling the spreading of HSV mutations is the exploitation of new drugs, and the possibility of enhancing their delivery through the encapsulation of drugs into nanoparticles, such as liposomes. In this work, liposomes were loaded with a series of 2-aminomethyl- 3-hydroxy-1,4-naphthoquinones derivatives with n-butyl (compound 1), benzyl (compound 2) and nitrobenzene (compound 3) substituents in the primary amine of naphthoquinone. They were previously identified to have significant inhibitory activity against HSV-1. All of the aminomethylnaphthoquinones derivatives encapsulated in the phosphatidylcholine liposomes were able to control the early and late phases of HSV-1 replication, especially those substituted with the benzyl (compound 2) and nitrobenzene (compound 3), which yields selective index values that are almost nine times more efficient than acyclovir. The growing interest of the industry in topical administration against HSV supports our choice of liposome as a drug carrier of aminomethylnaphthoquinones derivatives for formulations of in vivo pre-clinical assays. |
| Databáze: | OpenAIRE |
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