Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones

Autor: Tatjana Srdic-Rajic, Katarina Andjelkovic, Tamara R. Todorović, Manja Zec, Siniša Radulović, Aleksandra Konić-Ristić, Ivana Filipovic-Ljeskovic
Rok vydání: 2012
Předmět:
Cancer Research
Antiinvasive potential
Angiogenesis Inhibitors
Apoptosis
Metastasis
HeLa
Mice
0302 clinical medicine
Cell Movement
Coordination Complexes
Nickel
Breast
Neoplasm Metastasis
Selenium Compounds
chemistry.chemical_classification
0303 health sciences
biology
Chemistry
Tubulogenesis
VEGF
3. Good health
Zinc
Oncology
Matrix Metalloproteinase 9
Biochemistry
030220 oncology & carcinogenesis
Matrix Metalloproteinase 2
Molecular Medicine
Female
Antiangiogenic potential
Intracellular
Cadmium
Antineoplastic Agents
Breast Neoplasms
Matrix-metalloproteinase
Seleno
Cell Line
03 medical and health sciences
Metal complexes
Cell Line
Tumor
Selenosemicarbazones
medicine
Animals
Humans
030304 developmental biology
Semicarbazones
Pharmacology
Reactive oxygen species
Cancer
medicine.disease
biology.organism_classification
In vitro
Cell culture
Cancer cell
Cancer research
Cisplatin
Antimetastatic potential
HeLa Cells
Zdroj: Anti-Cancer Agents in Medicinal Chemistry
ISSN: 1871-5206
DOI: 10.2174/187152012803529682
Popis: Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
Databáze: OpenAIRE
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