Camu-camu (Myrciaria dubia) seeds as a novel source of bioactive compounds with promising antimalarial and antischistosomicidal properties
| Autor: | Aline Pereira Castro, Marcos José Marques, Luciana Azevedo, Mariana Araújo Vieira do Carmo, Takao Myoda, Caroline Andolfato Sanchez, Ihosvany Camps, Marina Fidelis, Fabio Antonio Colombo, Daniel Granato |
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| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Antioxidant 030309 nutrition & dietetics Antiparasitic medicine.drug_class Myrtaceae medicine.medical_treatment Alcohol Biology Antioxidants Antimalarials 03 medical and health sciences chemistry.chemical_compound 0404 agricultural biotechnology food Ic50 values medicine 0303 health sciences Traditional medicine Plant Extracts 04 agricultural and veterinary sciences Antimicrobial 040401 food science Myrciaria dubia chemistry Seeds Correlation analysis Food Science |
| Zdroj: | Food Research International. 136:109334 |
| ISSN: | 0963-9969 |
| DOI: | 10.1016/j.foodres.2020.109334 |
| Popis: | Parasitic diseases have attracted worldwide attention of their consequent impact on mortality and morbidity. Accordingly, several plants have been screened for antiparasitic activity aiming to create new alternatives for treatment. These diseases have been neglected and have not attracted worldwide attention (nowadays), the health concerns are focused in chronic diseases, but it is necessary to focus on parasitic diseases and look for prophylactic alternatives, such as plant extracts. Although camu-camu (Myrciaria dubia) seeds are a rich source of antioxidant antimutagenic, cytotoxic, anti-inflammatory, antimicrobial, antihypertensive and neuroprotective compounds, nothing is known about their antiparasitic effects. Thus, in the present study we aimed to evaluate five extracts of camu-camu seeds (100% water, 100% ethyl alcohol, 50% water + 50% ethyl alcohol, 25% water + 75% ethyl alcohol, and 75% water + 25% ethyl alcohol) in relation to their in vitro antimalarial, antischistosomicidal, leishmanicidal and anti-hemolytic effects. The extracts exhibited antischistosomicidal (ED50 values from 418.4 to >1000.0 µg/mL) and antimalarial activities (IC50 values from 24.2 to 240.8 µg/mL) for both W2 and 3D7 strains in all intra-erythrocytic stages. Correlation analysis showed that the toxic effects may mainly be attributed to methylvescalagin (r = −0.548 to −0.951, p |
| Databáze: | OpenAIRE |
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