The Impact Of Conjugate Vaccine On Carriage Of Haemophilus Influenzae Type B
| Autor: | M. L. Barbour, C. Coles, Derrick W. Crook, Richard T. Mayon-White, E. R. Moxon |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Haemophilus Infections health care facilities manpower and services Population Mothers medicine.disease_cause complex mixtures Nuclear Family Herd immunity Haemophilus influenzae Cohort Studies Conjugate vaccine Surveys and Questionnaires Tetanus Toxoid medicine Humans Immunology and Allergy education Bacterial Capsules Haemophilus Vaccines Family Health education.field_of_study Vaccines Conjugate Tetanus business.industry Vaccination Toxoid Infant bacterial infections and mycoses medicine.disease Virology carbohydrates (lipids) Infectious Diseases Carriage Case-Control Studies Carrier State Immunology Pharynx bacteria Female business |
| Zdroj: | Journal of Infectious Diseases. 171:93-98 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/171.1.93 |
| Popis: | Conjugate vaccines against Haemophilus influenzae type b (Hib) may modify Hib pharyngeal colonization. Hib colonization was compared in 371 infants and their families. In Oxfordshire, infants received PRP-T (polyribosylribitol phosphate conjugated to tetanus toxoid) and in Buckinghamshire they did not (controls). Infants were followed at 6, 9, and 12 months of age. Also, 6 unvaccinated Hib carriers were vaccinated and followed for 6 weeks. Hib acquisition was lower in vaccinees than controls (P < .01). During surveillance, 1.5% of vaccinees and 6.3% of controls carried Hib (P = .04). Among those with family Hib exposure, the carriage rates were 8.7% and 38.5% (P = .07), respectively. Hiv carriage rates were lower among vaccinees' unvaccinated siblings. Giving conjugate vaccine to a child carrying Hib did not rapidly terminate carriage. Thus, a primary means by which herd immunity to Hib is induced in a vaccinated population may be through reduction or delay in the initial acquisition of Hib. |
| Databáze: | OpenAIRE |
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