Drosophila immunity: two paths to NF-kappaB
| Autor: | Bruno Lemaitre, Ranjiv S. Khush, François Leulier |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Immunology
Biology Protein Serine-Threonine Kinases chemistry.chemical_compound Immune system Anti-Infective Agents Immunity Gene expression Immunology and Allergy Animals Drosophila Proteins Transcription factor Genetics Models Immunological NF-kappa B NF-κB biochemical phenomena metabolism and nutrition NFKB1 Proto-Oncogene Proteins c-rel I-kappa B Kinase chemistry Caspases bacteria Drosophila Signal transduction Gram-Negative Bacterial Infections Peptides Protein Processing Post-Translational Drosophila Protein Signal Transduction Transcription Factors |
| Zdroj: | Trends in immunology. 22(5) |
| ISSN: | 1471-4906 |
| Popis: | Recent studies of Drosophila immune responses have defined the immune deficiency (IMD) signaling pathway that mediates defense against Gram-negative bacterial infection. Like the Toll pathway, the IMD pathway regulates antimicrobial peptide gene expression via a Rel/nuclear factor (NF)-kappaB-like transcription factor. However, the two pathways do not appear to share any intermediate components. Maintaining distinct immune response pathways might be one mechanism by which flies mount adapted immune responses. |
| Databáze: | OpenAIRE |
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