Biochemical and Morphological Parameters of Inbred/Outbred Lines and DBCB Tetrahybrid Mouse in High-Sugar In Vivo Model of Metabolic Syndrome
| Autor: | Kh S Soto, I V Gmoshinskii, S A Apryatin, N V Trusov, D. B. Nikityuk, Beketova Na, A S Balakina, Kosheleva Ov, K V Mzhel'skaya |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Proteomics 0301 basic medicine Sucrose medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology Biology General Biochemistry Genetics and Molecular Biology Transcriptome Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo Internal medicine medicine Animals Abdominal obesity Metabolic Syndrome Mice Inbred BALB C 030109 nutrition & dietetics Vitamin E Fatty liver General Medicine medicine.disease Fatty Liver Mice Inbred C57BL Disease Models Animal Endocrinology Liver chemistry Mice Inbred DBA Female medicine.symptom Metabolic syndrome Steatosis |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 166:96-101 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Integral, biochemical, and morphological parameters and concentrations of vitamins, particularly lipid soluble vitamins, were analyzed in female mice of inbred DBA/2J line, outbred ICR-1 (CD-1) line, and DBCB tetrahybrid mice on the in vivo model of metabolic syndrome induced by consumption of 30% sucrose for 2 days. In contrast to inbred and outbred lines, DBCB tetrahybrid mice developed abdominal obesity, hypercholesterolemia, and pronounced morphological picture of fatty liver disease. The lipid-coupled transport of vitamin E to the liver is also enhanced in these animals, which compensated decreased supply of vitamin E to the liver under conditions of high-sugar ration. The observed interstrain differences can be related to genetic features of the used mouse lines and DBCB tetrahybrid mice and require further genomic, transcriptomic, proteomic, and morphological studies. The results of the study based on the in vivo model of metabolic syndrome allow identifying the key biomarkers for complex diagnostics and prognosis of metabolic syndrome complications, such as nonalcoholic steatosis of the liver. |
| Databáze: | OpenAIRE |
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