Toll-Like receptor 4 (TLR4) polymorphism rs2149356 and risk of gout in a Spanish cohort

Autor:	Rosa J. Torres
Rok vydání:	2020
Předmět:	Male Gout Arthritis 010402 general chemistry Polymorphism Single Nucleotide 01 natural sciences Biochemistry Cohort Studies Gene Frequency Genetics medicine Humans SNP Genetic Predisposition to Disease Hyperuricemia Toll-like receptor Kidney 010405 organic chemistry Chemistry General Medicine Middle Aged medicine.disease 0104 chemical sciences Toll-Like Receptor 4 medicine.anatomical_structure Spain Cohort Immunology TLR4 Molecular Medicine Female
Zdroj:	Nucleosides, Nucleotides & Nucleic Acids. 39:1424-1431
ISSN:	1532-2335 1525-7770
DOI:	10.1080/15257770.2020.1780438
Popis:	Gout is the most common arthritis and it is associated to urate monosodium crystals deposits in articulations, kidney and soft tissue. The urate monosodium crystals deposit initiates an inflammatory response; mediated by NLRP3 inflammasome, with the release of interleukin 1β. Toll-like receptor 4 (TLR4) is involved in this response. Although serum urate level is a strong predictor of incident gout, only about half of those with serum urate concentrations ≥10mg/dL develop clinically evident gout over 15 years. Therefore, it has been postulated that other factors, including genetic or immunity related factors, seems to be necessary to the apparition of the acute gout flare beside hyperuricemia. The association of TLR4 single nucleotide polymorphism (SNP) rs2149356 and gout risk is controversial with different results according to different populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f6f7263d2cce65041782e7d9cb006c https://doi.org/10.1080/15257770.2020.1780438 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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