Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease
| Autor: | Julia Terreros-Roncal, Jesús Avila, Noemí Pallas-Bazarra, Marta Bolós, María Llorens-Martín, Cátia M. Teixeira |
|---|---|
| Přispěvatelé: | Ministerio de Economía y Competitividad (España), Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Alzheimer's Association, Association for Frontotemporal Degeneration (US) |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Morphology Neurogenesis Disease Biology Hippocampal formation Neuroprotection Hippocampus Pathogenesis 03 medical and health sciences 0302 clinical medicine Atrophy Alzheimer Disease medicine Animals Humans GSK-3 General Neuroscience Dentate gyrus General Medicine medicine.disease Entorhinal cortex Granule neuron Psychiatry and Mental health Clinical Psychology 030104 developmental biology Adult hippocampal neurogenesis Geriatrics and Gerontology Tau Neuroscience Alzheimer’s disease 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's disease : JAD. 64(s1) |
| ISSN: | 1875-8908 |
| Popis: | Neurogenesis occurs in a limited number of brain regions during adulthood. Of these, the hippocampus has attracted great interest due to its involvement in memory processing. Moreover, both the hippocampus and the main area that innervates this structure, namely the entorhinal cortex, show remarkable atrophy in patients with Alzheimer's disease (AD). Adult hippocampal neurogenesis is a process that continuously gives rise to newborn granule neurons in the dentate gyrus. These cells coexist with developmentally generated granule neurons in this structure, and both cooperative and competition phenomena regulate the communication between these two types of cells. Importantly, it has been revealed that GSK-3β and tau proteins, which are two of the main players driving AD pathology, are cornerstones of adult hippocampal neurogenesis regulation. We have shown that alterations either promoting or impeding the actions of these two proteins have detrimental effects on the structural plasticity of granule neurons. Of note, these impairments occur both under basal conditions and in response to detrimental and neuroprotective stimuli. Thus, in order to achieve the full effectiveness of future therapies for AD, we propose that attention be turned toward identifying the pathological and physiological actions of the proteins involved in the pathogenesis of this condition. Spanish Ministry of Economy and Competitiveness (SAF-2014-53040-P (Jesu´s A´ vila) and RYC-2015-17189 (María Llorens-Mart´ın)); the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, Spain) (Jesu´s Avila); the Alzheimer’s Association (2015-NIRG-340709 (Mar´ıa Llorens-Mart´ın)); and the Association for Frontotemporal Degeneration (2016 Basic Science Pilot Grant Award (María Llorens-Martín)). |
| Databáze: | OpenAIRE |
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