Aggregation-Induced Emission-Based Chemodosimeter Approach for Selective Sensing and Imaging of Hg(II) and Methylmercury Species
| Autor: | Dipratn G. Khandare, Hrishikesh Joshi, Mainak Banerjee, Rishabh Gupta, Ram U. Gawas, Amrita Chatterjee, Anasuya Ganguly, Starlaine C. Mascarenhas |
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| Rok vydání: | 2017 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Inorganic chemistry chemistry.chemical_element 02 engineering and technology 010402 general chemistry Photochemistry 01 natural sciences Analytical Chemistry chemistry.chemical_compound Transmetalation Limit of Detection Animals Humans Aggregation-induced emission Methylmercury Zebrafish Fluorescent Dyes Aryl Tetraphenylethylene Mercury Methylmercury Compounds 021001 nanoscience & nanotechnology Boronic Acids 0104 chemical sciences Mercury (element) HEK293 Cells chemistry Microscopy Fluorescence 0210 nano-technology Boronic acid |
| Zdroj: | Analytical chemistry. 89(23) |
| ISSN: | 1520-6882 |
| Popis: | Methylmercury (CH3Hg+) is the common form of organic mercury and is more toxic than its inorganic or elemental forms. Mercury is emanated in the course of various natural events and human activities and converts to methylmercury by anaerobic organisms. CH3Hg+ are ingested by fish and subsequently bioaccumulated in their tissue and, eventually, enter the human diet, causing serious health issues. Therefore, selective and sensitive detection of bioaccumulated CH3Hg+ in fish samples is essential. Herein, the development of a simple, highly sensitive and selective aggregation-induced emission (AIE)-based turn-on probe for both inorganic mercury ions and organicmercury species is reported. The probe’s function is based on mercury ion-promoted transmetalation reaction of aryl boronic acid. The probe, a tetraphenylethylene (TPE)–monoboronic acid (1), was successfully utilized for AIE-based fluorescence imaging study on methylmercury-contaminated live cells and zebrafish for the first time. Both Hg(II) and CH3Hg+... |
| Databáze: | OpenAIRE |
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