Hyperprealbuminemia, euthyroid hyperthyroxinemia, Zollinger-Ellison-like syndrome and hypercorticism in a pancreatic endocrine tumour
| Autor: | Rolf C. Gaillard, A. Burger, R. Docter, M. Griessen, Ph. Maye, A. Bisetti, M. F. Pelte |
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| Rok vydání: | 1989 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Adrenocortical Hyperfunction Endocrinology Diabetes and Metabolism Immunoenzyme Techniques Zollinger-Ellison Syndrome Thyroxine-Binding Proteins Endocrinology Internal medicine Gastrins medicine Humans Prealbumin Secretion Euthyroid hyperthyroxinemia Gastrin biology medicine.diagnostic_test business.industry Multiple Endocrine Neoplasia General Medicine Middle Aged Pancreatic Neoplasms Hyperthyroxinemia Transthyretin Serum protein electrophoresis Concomitant biology.protein Immunohistochemistry business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Acta Endocrinologica. 120:87-91 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1200087 |
| Popis: | Prealbumin, one of the main thyroxine transport proteins, has recently been shown to be a valuable immunohistochemical marker of neuroendocrine tumours. We report the case of a multisecretory pancreatic endocrine tumour whose prealbumin secretion was so high that it produced a peak on routine serum protein electrophoresis and induced a euthyroid hyperthyroxinemia. The maximal binding capacity of prealbumin for thyroxine was indeed markedly increased, whereas its affinity for this hormone was normal. The tumour was associated with gastric hyperacidity and hypergastrinemia thereby evoking a Zollinger-Ellison syndrome. The secretin stimulation test and gastrin tumoural immunohistochemistry were, however, negative. We suggest that the concomitant tumoural production of gastrin-releasing peptide was responsible for the gastric hyperacidity and hypergastrinemia. This hormone probably also accounted for a moderate hypercorticism. |
| Databáze: | OpenAIRE |
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