Harnessing SLE Autoantibodies for Intracellular Delivery of Biologic Therapeutics
| Autor: | Renata E. Gordon, Iqbal S. Grewal, Russell B. Lingham, Sanjaya Singh, Jennifer F. Nemeth |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Intracellular localization Cell Intracellular Space Bioengineering 02 engineering and technology Cell membrane 03 medical and health sciences Drug Delivery Systems medicine Humans Lupus Erythematosus Systemic Available drugs Biological Products biology business.industry Autoantibody 021001 nanoscience & nanotechnology 030104 developmental biology medicine.anatomical_structure Antibodies Antinuclear Cancer research biology.protein Antibody 0210 nano-technology business Intracellular Biotechnology |
| Zdroj: | Trends in Biotechnology. 39:298-310 |
| ISSN: | 0167-7799 |
| DOI: | 10.1016/j.tibtech.2020.07.003 |
| Popis: | Intracellular delivery of therapeutic antibodies is highly desirable but remains a challenge for biomedical research and the pharmaceutical industry. Approximately two-thirds of disease-associated targets are found inside the cell. Difficulty blocking these targets with available drugs creates a need for technology to deliver highly specific therapeutic antibodies intracellularly. Historically, antibodies have not been believed to traverse the cell membrane and neutralize intracellular targets. Emerging evidence has revealed that anti-DNA autoantibodies found in systemic lupus erythematosus (SLE) patients can penetrate inside the cell. Harnessing this technology has the potential to accelerate the development of drugs against intracellular targets. Here, we dissect the mechanisms of the intracellular localization of SLE antibodies and discuss how to apply these insights to engineer successful cell-penetrating antibody drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect