Potential asbestos exposure among patients with primary lung cancer in Japan
| Autor: | Yoshihito Yamashita, Atsushi Ishimine, Mitsuhiko Funakoshi, Kazuhiko Satomi, Makoto Hattori, Kenji Nakamura, Noriyuki Tannai, Kichinori Hasegawa, Akio Koike, Masami Fujii, Akihiko Tamura, Narufumi Suganuma, J-P Naw Awn, Harukazu Hirano, Masanobu Funakoshi, Yasuma Fukuchi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms Original Population Computed tomography Pleural plaques medicine.disease_cause Asbestos 03 medical and health sciences 0302 clinical medicine Japan Occupational Exposure Internal medicine Prevalence Humans Medicine In patient 030212 general & internal medicine Occupations education Lung cancer Lung Aged Retrospective Studies education.field_of_study medicine.diagnostic_test business.industry Construction Industry Public Health Environmental and Occupational Health Mediastinum Retrospective cohort study Middle Aged Pleural Diseases respiratory system medicine.disease 030210 environmental & occupational health respiratory tract diseases Occupational Diseases medicine.anatomical_structure Pleura Female business |
| Zdroj: | Journal of Occupational Health |
| ISSN: | 1348-9585 1341-9145 |
| DOI: | 10.1539/joh.2017-0199-oa |
| Popis: | Objective To investigate the extent of asbestos exposure among patients with primary lung cancer in Japan. Methods A retrospective estimation of potential asbestos-exposed individuals, as determined by the presence of pleural plaques identified on chest computed tomography (CT), was conducted on 885 pathologically confirmed primary lung cancer patients (mean age 71.3 years, 641 males). All patients were diagnosed at 29 hospitals across Japan between 2006 and 2007. Since these hospitals belong to the Japan Federation of Democratic Medical Institutions (MIN-IREN), an organization of medical institutions for workers, the study subjects may contain a higher proportion of workers than the general population. Results Pleural plaques were identified in 12.8% of subjects (15.8% in males and 4.9% in females), consisting exclusively of cases older than 50 years. They were found most frequently on the chest wall pleura (96.5%), followed by the diaphragm (23.9%) and mediastinum (9.7%). Calcifications were seen in 47 cases (41.6%). The highest prevalence of pleural plaques was seen among workers from construction-related fields (37.7%). No distinct lung cancer histology was observed in patients with pleural plaques. Coexistence of pleural plaques and small irregular opacities was observed in 2.5% of subjects. Conclusion In a Japanese population representing more workers than general Japanese, 12.8% of patients with primary lung cancer may have experienced asbestos exposure at some time in the past. Special medical attention should be paid to individuals with a history of employment in construction-related occupations, as workers in this sector showed the highest prevalence of pleural plaques. |
| Databáze: | OpenAIRE |
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